Changing the General Factor of Personality and the c-fos Gene Expression with Methylphenidate and Self-Regulation Therapy

6533b830fe1ef96bd129666a

RESEARCH PRODUCT

Changing the General Factor of Personality and the c-fos Gene Expression with Methylphenidate and Self-Regulation Therapy

Salvador Amigo Joan C. Micó Antonio Caselles

subject

Male Linguistics and Language Subjective variables media_common.quotation_subject Gene Expression Models Psychological Hierarchical structure of the Big Five c-Fos Dynamic model Language and Linguistics Developmental psychology Terapia de auto-regulación Gene expression Conditioning Psychological Self-regulation therapy medicine Personality Humans Personalidad General Psychology media_common Modelo dinámico biology C-fos Methylphenidate Genes fos Middle Aged Up-Regulation Coupled differential equations Expression (architecture)biology.protein Methylphenidate Factor general de personalidad Central Nervous System Stimulants General factor of personality Psychology MATEMATICA APLICADA Neuroscience Proto-Oncogene Proteins c-fos Metilfenidato medicine.drug Personality

description

[EN] A deepening in the biological nature of the general factor of personality (GFP) is suggested: the activation level of the stress system is here represented by the gene expression of c-fos. The results of a single case experimental design are reported. A model of four coupled differential equations that explains the human personality dynamics as a consequence of a single stimulant drug intake has been fitted to psychological and biological experimental data. The stimulant-drug conditioning and its adaptation to the considered mathematical model is also studied for both kinds of measures. The dynamics of the cfos expression presents a similar pattern to the dynamics of the psychological measures of personality assessed by the GFP-FAS (Five-Adjective Scale of the General Factor of Personality) as a consequence of a single dose of stimulant drug (methylphenidate). The model predicts similar dynamic patterns for both psychological and biological measures. This study proves that describing mathematically the dynamics of the effects of a stimulant drug as well as the effects of a conditioning method on psychological or subjective variables and on gene expression is possible. It verifies the existence of biological mechanisms underlying the dynamics of the General Factor of Personality (GFP).

year	journal	country	edition	language
2012-01-01

10.5209/rev_sjop.2012.v15.n2.38896 http://hdl.handle.net/10251/36790