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RESEARCH PRODUCT

Antibiotic as Ligand. Coordinating Behavior of the Cephalexin Towards Zn(II) and Cd(II) Ions

Joaquín BorrásM.j. Lozano

subject

Models MolecularCephalexinBicyclic moleculeLigandChemistryPotentiometric titrationInorganic chemistryMolecular ConformationInfrared spectroscopyLigandsBiochemistryInorganic ChemistryNMR spectra databaseMetalZincStability constants of complexesvisual_artvisual_art.visual_art_mediumThermal stabilityCopperSoftwareNuclear chemistry

description

The complex formation equilibria of Zn(II) and Cd(II) with cephalexin have been studied through potentiometric titrations. Experimental data were analyzed using the least squares computer program SUPERQUAD. The stability constants were 1g beta ZnCEX+ = 2.40, 1g beta Zn(CEX)(OH) = -4.54, 1g beta CdCEX+ = 2.18, and 1g beta Cd(CEX)(OH) = -5.18 (I = 0.1 M NaNO3), CEX complexes of formulae Zn(CEX)2(3)H2O and Cd(CEX)(OH)H2O have been synthesized and characterized by elemental analysis, IR spectra, conductivity measurements, and electronic and NMR spectra. The thermal behavior of the synthesized compounds were studied by TGA and DTA. We conclude that the metal ion interacts with the amido group of CEX.

yearjournalcountryeditionlanguage
1987-11-01Journal of Inorganic Biochemistry
https://doi.org/10.1016/0162-0134(87)80004-1