6533b830fe1ef96bd12967a4
RESEARCH PRODUCT
Different intracellular cation-content present in right and left ventricle dependent on varying extracellular Ca2+-concentrations.
Karsten SchrörRolf KrebsAbbas Sadat-khonsarisubject
Muscle tissuemedicine.medical_specialtyPotassiumHeart VentriclesGuinea Pigschemistry.chemical_elementCalciumRight ventricular myocardiumGuinea pig heartInternal medicinemedicineExtracellularAnimalsMolecular BiologyMyocardiumSodiumMyocardial ContractionEndocrinologymedicine.anatomical_structurechemistryVentriclePotassiumCalciumCardiology and Cardiovascular MedicineExtracellular SpaceIntracellulardescription
Abstract The different intracellular cation-contents present in the right and left ventricle depend on varying Ca2+-concentrations. The effect of extracellular Ca2+-concentrations varied within the physiological range has been studied on an isolated guinea pig heart preparation, showing excellent stable experimental conditions. By increasing the extracellular Ca2+-concentration from 0.45 m m to 3.6 m m the tissue contents of calcium and potassium were increased dependent on [Ca]e whereas that of Na was reduced. This was due to a change in the composition of the intracellular cations as the extracellular space (inulin) and water-content of the heart muscle tissue were not influenced by increasing the extra-cellular Ca2+-concentration. At any given [Ca]e the Ca- and Na-content of the right ventricular myocardium was higher than that in the left. The ratio Ca right Ca left varied from 2.0 at 0.45 m m to 1.6 at 3.6 m m [Ca]e. The left ventricular contractile force showed a log linear relationship to Canet as well as [Na]i.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1979-01-01 | Journal of molecular and cellular cardiology |