Tower of London test: a comparison between conventional statistic approach and modelling based on artificial neural network in differentiating fronto-temporal dementia from Alzheimer's disease

6533b830fe1ef96bd129682f

RESEARCH PRODUCT

Tower of London test: a comparison between conventional statistic approach and modelling based on artificial neural network in differentiating fronto-temporal dementia from Alzheimer's disease

M Franceschi P Caffarra R Savarè R Cerutti E Grossi A Tol Research Group Padovani A Nieddu F Clerici G Bottini F Lamenza G Gambina G Magnani R Perri M Alberoni M Gallucci F Scoppa S Lorusso G Murialdo Cester A. Stracciari A C Mina G Tripi Lp De Vreese R. Monastero Ildebrando Appollonio

subject

Male Models Neurological neuropsychology Neurosciences. Biological psychiatry. Neuropsychiatry Tower of London Neuropsychological Tests frontotemporal dementia Sensitivity and Specificity Diagnosis Differential Executive Function Alzheimer's disease frontotemporal dementia Tower of London neuropsychology executive functions Alzheimer Disease mental disorders Humans Aged MED/26 - NEUROLOGIA Aged 80 and over General Medicine Middle Aged executive functions Neuropsychology and Physiological Psychology Neurology Nonlinear Dynamics test torre di Londra neuropsicologia demenza Female Settore MED/26 - Neurologia Neurology (clinical)Neural Networks Computer Alzheimer’s disease RC321-571 Research Article

description

The early differentiation of Alzheimer’s disease (AD) from frontotemporal dementia (FTD) may be difficult. The Tower of London (ToL), thought to assess executive functions such as planning and visuo-spatial working memory, could help in this purpose. Twentytwo Dementia Centers consecutively recruited patients with early FTD or AD. ToL performances of these groups were analyzed using both the conventional statistical approaches and the Artificial Neural Networks (ANNs) modelling. Ninety-four non aphasic FTD and 160 AD patients were recruited. ToL Accuracy Score (AS) significantly (p < 0.05) The use of hidden information contained in the different items of ToL and the non linear processing of the data through ANNs allows a high discrimination between FTD and AD in individual patients. However, the discriminant validity of AS checked by ROC curve analysis, yielded no significant results in terms of sensitivity and specificity (AUC 0.63). The performances of the 12 Success Subscores (SS) together with age, gender and schooling years were entered into advanced ANNs developed by Semeion Institute. The best ANNs were selected and submitted to ROC curves. The nonlinear model was able to discriminate FTD from AD with an average AUC for 7 independent trials of 0.82. The use of hidden information contained in the different items of ToL and the non linear processing of the data through ANNs allows a high discrimination between FTD and AD in individual patients.

year	journal	country	edition	language
2011-05-01

10.3233/ben-2011-0327 http://hdl.handle.net/10447/104091