6533b830fe1ef96bd1296e7d

RESEARCH PRODUCT

Effect of poly(I).poly(C12U) (Ampligen) on enteric virus (rotavirus, poliovirus and Coxsackie B3 virus) infections

A. MukoyamaS. YamazakiWerner E.g. MüllerH. UshijimaK. Konishi

subject

biologyvirusesPoliovirusRhabdoviridaebiology.organism_classificationmedicine.disease_causeApplied Microbiology and BiotechnologyVirologyVirusIn vitroMicrobiologyVesicular stomatitis virusInterferonRotavirusmedicineEnterovirusmedicine.drug

description

The effects of poly(1)-poly(C 12 U) (Ampligen) on infections with enteric viruses (rotavirus, poliovirus and Coxsackie B3 virus) were studied in vitro. Ampligen exhibited antiviral activity against rotavirus, especially when treatment was performed prior to inoculation of the virus. It was partially effective against Coxsackie B3 virus, but not against poliovirus. It is suggested that the observed effects may be due to the production of interferon induced by Ampligen

yearjournalcountryeditionlanguage
1994-11-01Letters in Applied Microbiology
https://doi.org/10.1111/j.1472-765x.1994.tb00483.x