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RESEARCH PRODUCT
Synthesis and characterization of water-swellable?,?-polyasparthydrazide derivatives
Giuseppe SpadaroGaetano GiammonaVincenzo TomarchioClelia DispenzaGiovanna Pitarresisubject
chemistry.chemical_classificationPolymers and PlasticsScanning electron microscopetechnology industry and agriculturemacromolecular substancesPolymerBuffer solutionMicrostructureIn vitrochemistry.chemical_compoundColloid and Surface ChemistrychemistrySelf-healing hydrogelsMaterials ChemistrymedicineGlutaraldehydePhysical and Theoretical ChemistrySwellingmedicine.symptomNuclear chemistrydescription
α, β-polyasparthydrazide (PAHy) was crosslinked by glutaraldehyde to form water-swellable materials possessing a three-dimensional molecular network. Different crosslinking degrees were prepared varying glutaraldehyde/PAHy ratio and samples containing 5-fluorouracil were obtained by incorporating the drug into the polymer networks during the crosslinking reaction. All samples were characterized by swelling tests, thermal, x-ray and SEM analysis. Their microstructure was observed through scanning electron microscopy. Furthermore, for samples containing the anticancer drug,in vitro release studies were performed in pH 7.4 buffer solution.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1995-06-01 | Colloid & Polymer Science |