6533b830fe1ef96bd1297198
RESEARCH PRODUCT
Diversity in AMPA receptor complexes in the brain.
Eric JacobiJakob Von Engelhardtsubject
0301 basic medicineProtein subunitCellGatingAMPA receptorBiology03 medical and health sciences0302 clinical medicinemedicineAnimalsHumansReceptors AMPAReceptormusculoskeletal neural and ocular physiologyGeneral NeuroscienceBrainGenetic VariationSubcellular localizationTransport proteinProtein Transport030104 developmental biologymedicine.anatomical_structurenervous systemNeuroscience030217 neurology & neurosurgeryFunction (biology)description
AMPA receptor (AMPAR) complexes comprise four of the AMPAR subunits GluA1-4 and several additional interacting proteins. Subunit composition determines AMPAR function. However, AMPAR function depends to a large extent also on interacting proteins, which influence trafficking to the cell surface, activity-dependent subcellular localization and gating of AMPARs. In this review we report about recent findings on the diversity of AMPAR complexes that allow us to better understand functional properties of native receptors in the brain.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-08-01 | Current opinion in neurobiology |