DNA-binding and DNA-protection properties of novel 1,4-dihydropyridine derivatives and nucleoside analogues

6533b830fe1ef96bd12974e7

RESEARCH PRODUCT

DNA-binding and DNA-protection properties of novel 1,4-dihydropyridine derivatives and nucleoside analogues

Elīna ĻEonova

subject

Bioloģija Biology Molecular Biology

description

Nesen iegūtie dati liecina, ka daži savienojumi, kuriem piemīt antioksidatīvas un antimutagēnas īpašības, spēj tieši mijiedarboties ar DNS. Šī pētījuma mērķis bija izpētīt dažādu 1,4-dihidropiridīna (1,4-DHP) atvasinājumu spēju mijiedarboties ar DNS un papildus novērtēt 1,4-DHP spēju pasargāt DNS oksidatīvā stresa apstākļos. Tika atklāts, ka daži 1,4-DHP intensīvi mijiedarbojas ar DNS un effektīvi pasargā šūnu DNS integritāti no oksidatīvā stresa izraisītajiem bojājumiem un paātrina reparācijas ātrumu pēc peroksinitrīta izraisītajiem bojājumiem. Pamatojoties uz iegūtajiem rezultātiem, var pieņemt, ka antimutagēnu mijiedarbība ar DNS varētu būt iespējams DNS pasargāšanas mehānisms. Atslēgvārdi: 1,4-dihidropiridīni, mijiedarbība ar DNS, antimutagēni, antioksidanti, peroksinitrīts, DNS reparācija, DNS pasargāšana

year	journal	country	edition	language
2019-01-01

https://dspace.lu.lv/dspace/handle/7/48875

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