6533b830fe1ef96bd129756a

RESEARCH PRODUCT

SYNTHESIS AND EVALUATION OF CURCUMIN ANALOGUES AS NEURO-PROTECTIVE AGENTS FOR THE ALZHEIMER'S DISEASE

Valentina GiacaloneAngela AccardoAnnamaria MartoranaAntonino LauriaAnna Maria AlmericoSilvestre BuscemiAntonio Palumbo Piccionello

subject

Alzheimer's Disease curcumin curcumin-like compounds amyloid peptideSettore CHIM/06 - Chimica OrganicaSettore CHIM/08 - Chimica Farmaceutica

description

The Alzheimer's disease (AD) is the most common form of senile dementia.1 The most important role in AD is played by the aggregation process of beta-amyloid peptide (Aß), responsible for the cytotoxic effects.2 In this context, the purpose of this study was to synthesize new dicarbonyl compounds 1 structurally related to curcumin3, with anti-aggregation activity against Aß.Parallel studies involve the synthesis of heterocyclic-based curcumin-like molecules that are currently under investigation by means of in silico protocols in order to rationalize the ligand-biological target interactions.

yearjournalcountryeditionlanguage
2013-01-01
http://hdl.handle.net/10447/96982