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RESEARCH PRODUCT
Natural Product Synthesis on Polymeric Supports—Synthesis and Biological Evaluation of an Indolactam Library
Daniel Alonso-díazThomas HergetHerbert WaldmannNils GriebenowBenjamin Meseguersubject
Indole testNatural productIndole alkaloidStereochemistryEnantioselective synthesisTotal synthesisRegioselectivityGeneral ChemistryCombinatorial chemistryCatalysischemistry.chemical_compoundSolid-phase synthesischemistryAminationdescription
Potent activators of protein kinase C in fibroblasts: This property was determined for several indolactam V analogues (1) with a new cell-based assay system. This tumor-promoting indole alkaloid and analogues thereof can be synthesized efficiently on the solid phase. The key steps of the combinatorial approach are a regioselective amination of the indole ring and an enantioselective enzymatic reaction.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1999-10-04 | Angewandte Chemie International Edition |