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RESEARCH PRODUCT
Long-Term Potentiation in the Recurrent Inhibitory Circuit of the Dentate Gyrus
H. L. HaasM. L. ErringtonT. V. P. Blisssubject
Chemistrymusculoskeletal neural and ocular physiologyDentate gyrusHippocampusLong-term potentiationPerforant pathInhibitory postsynaptic potentialGranule cellmedicine.anatomical_structurenervous systemBasket cellmedicineExcitatory postsynaptic potentialNeurosciencedescription
The question of whether long-term potentiation occurs in the inhibitory circuits of the hippocampus remains controversial. Buszaki and Eidelberg (1982), recording extracellularly from putative interneurones (basket cells) in the dentate gyrus and area CAl of the anaesthetized rat, found a prolonged increase in probability of cell firing to afferent stimulation after high-frequency stimulation of Schaffer-commissural fibres, and concluded that LTP occurs at excitatory feedforward synapses onto interneurones. Similarly, Kairis et al (1987) have presented field potential evidence for LTP in feedforward synapses onto inhibitory neurones in the dentate gyrus of the anaesthetized rat. In the hippocampal slice, on the other hand, the available evidence suggests that LTP of feedforward synapses does not occur in area CAl (Yamamoto and Chujo, 1978; Misgeld et al., 1979; Haas and Rose, 1982; Griffith et al., 1986; Abraham et al., 1987). In this paper we present in vivo and in vitro evidence that LTP occurs in the circuit mediating recurrent inhibition in the dentate gyrus.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1988-01-01 |