6533b830fe1ef96bd1297b6c

RESEARCH PRODUCT

Treatment of pituitary resistance to thyroid hormone (PRTH) in an 8-year-old boy.

Joachim PohlenzD Knöbl

subject

MaleThyroid Hormone Resistance Syndromeendocrine systemmedicine.medical_specialtyPituitary glandendocrine system diseasesArginineTreatment outcomeMolecular Sequence DataPathogenesisInternal medicineMedicineHumansAmino Acid SequenceDextrothyroxineThyroid-stimulating hormone secretionChildbusiness.industryThyroidGeneral MedicineD-Thyroxinemedicine.anatomical_structureEndocrinologyThyrotoxicosisTreatment OutcomePediatrics Perinatology and Child HealthMutationbusinessHormone

description

We report on an 8-year-old boy with pituitary resistance to thyroid hormone (PRTH) having a cysteine for arginine substitution at codon 320 in the TR-beta gene who was presented because of thyrotoxicosis. Due to its suppressive effect on the pituitary thyrotropin secretion, treatment with D-thyroxine (D-T4) was started. After a few days, clinical euthyroidism was achieved but thyroid stimulating hormone secretion was not suppressed. Symptoms of thyrotoxicosis relapsed when therapy was interrupted so that therapy with D-T4 was reinstituted and continued to date. Symptoms did not recur, and the psychomotor development proceeded normally. D-T4 should therefore be considered in the treatment of thyrotoxicosis in PRTH.

yearjournalcountryeditionlanguage
1996-03-01Acta paediatrica (Oslo, Norway : 1992)
10.1111/j.1651-2227.1996.tb14043.xhttps://pubmed.ncbi.nlm.nih.gov/8696005