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RESEARCH PRODUCT
Major histocompatibility complex regulation of interleukin-5 production in the mouse.
Guido SireciFrancesco DieliCesira T. BonannoDomenico LioAlfredo Salernosubject
Immunoglobulin AMaleImmunologyMajor histocompatibility complexPicryl chlorideOxazoloneMajor Histocompatibility Complexchemistry.chemical_compoundMiceAntigenSpecies SpecificityImmunology and AllergyAnimalsInterleukin 5Mice Inbred BALB CbiologyH-2 AntigensInterleukinIn vitroImmunoglobulin AchemistryGene Expression RegulationImmunologybiology.proteinMice Inbred CBAInterleukin-5description
Lymph node cells of CBA (H-2k), but not of BALB/c (H-2d) mice immunized epicutaneously with picryl chloryde secrete interleukin (IL)-5 when stimulated with the specific antigen in vitro. The low IL-5 production in BALB/c mice persists when either picryl chloride or the unrelated antigen oxazolone are used, when the amount of antigen in vitro is varied and when a secondary response is studied. The difference in IL-5 production maps to the major histocompatibility complex (MHC) in the congenic BALB/b, BALB/c and BALB/k mice. Furthermore, lymph node cells from (k × d) F1 mice produce IL-5 when stimulated by antigen presented on H-2k but not on H-2d antigen-presenting cells. Finally, the low IL-5 production in vitro in BALB/c mice is correlated with low picryl-specific IgA levels in vivo, which otherwise are ten times greater in CBA and BALB/k mice. The influence of MHC on IL-5 production and IgA secretion in the mouse might be a possible basis for the association of MHC with IgA deficiency in humans.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1993-11-01 | European journal of immunology |