6533b831fe1ef96bd1298192

RESEARCH PRODUCT

kLa MEASUREMENT IN BIOREACTORS

F ScargialiA BusciglioF GrisafiA Brucato

subject

lcsh:Computer engineering. Computer hardwareMIXINGSettore ING-IND/25 - Impianti Chimicilcsh:TP155-156Stirred tank reactorlcsh:TK7885-7895Gas-liquid mass transfer mixingMASS TRANSPORT COEFFICIENTGas-liquid dispersionComputingMethodologies_DOCUMENTANDTEXTPROCESSINGlcsh:Chemical engineeringComputingMilieux_MISCELLANEOUSComputingMethodologies_COMPUTERGRAPHICS

description

For accurately measuring kLa in bioreactors the dynamic pressure method (DPM) was introduced by Linek et al. (1993). In this work a simplified version of the same method is discussed. With respect to the original DPM, the simplified version greatly simplifies data treatment. In fact final constant slope observable in the usual semi-log diagram of residual driving force versus time may be simply corrected to obtain the real kLa value with negligible inaccuracy. Experimental data obtained on a lab-size stirred tank reactor confirm all model predictions, including the feature that the adoption of large pressure changes may lead to a better accuracy.

yearjournalcountryeditionlanguage
2010-04-01
10.3303/cet1020039http://hdl.handle.net/10447/57726