6533b831fe1ef96bd12985ac
RESEARCH PRODUCT
Dimethyl 2,2′-[Carbonylbis(azanediyl)](2S,2′S)-bis[3-(4-hydroxyphenyl)propanoate]
Bartolo GabrieleAntonio Palumbo PiccionelloCarla CarfagnaNicola Della CaKatia F. GioiaRaffaella Mancusosubject
Oxidative carbonylationchemistry.chemical_elementCarbonylation010402 general chemistry01 natural sciencesBiochemistryMedicinal chemistryCatalysischemistry.chemical_compoundlcsh:Inorganic chemistryUreaPhysical and Theoretical ChemistryL‐tyrosine methyl ester010405 organic chemistryureasOrganic ChemistrySettore CHIM/06 - Chimica Organicalcsh:QD146-1970104 chemical sciencesSolventchemistryl-tyrosine methyl esterCarbonylationPalladiumDerivative (chemistry)Palladiumdescription
The thus‐far unknown ureic derivative dimethyl 2,2′‐[carbonylbis(azanediyl)](2S,2′S)‐ bis[3‐(4‐hydroxyphenyl)propanoate] has been efficiently synthesized by enantiospecific oxidative carbonylation of readily available L‐tyrosine methyl ester, using a very simple catalytic system (PdI2 in conjunction with KI) under relatively mild conditions (100 °C for 5 h in DME as the solvent and under 20 atm of a 4:1 mixture CO‐air).
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2018-01-01 | Molbank |