Hepatīta B kora antigēna veidoto vīrusveidīgo daļiņu modificēšana vakcīnu prototipa izstrādei

6533b831fe1ef96bd12988e7

RESEARCH PRODUCT

Hepatīta B kora antigēna veidoto vīrusveidīgo daļiņu modificēšana vakcīnu prototipa izstrādei

Kristīne Liepiņa

subject

chemical conjugation adjuvants envelope domain III Bioloģija Dengue virus HBcAg VLP

description

DENV vakcīnu izveide balstās galvenokārt, izmantojot dzīvus novājinātus vīrusus. 2015. gadā tika reģistrēta pirmā tetravalenta novājināta denges vīrusa vakcīna. Kā drošāks vakcīnas veids ir subvienību vakcīnas. Daudzsološākais DENV antigēns subvienību vakcīnas izveidē ir apvalka proteīna III domēns. Lai palielinātu antigēna subvienības imunogenitāti, tiek izmantotas vīrusveidīgās daļiņas (VLP) kā svešu antigēnu nesēji. Tā kā VLP ir pašnereplicējošas, tās tiek uzskatītas par drošākiem kandidātiem vakcīnu izveidē, salīdzinot ar dzīviem novājinātiem vīrusiem. Maģistra darba mērķis bija iegūt 2. serotipa denges vīrusa apvalka III domēnu (DV2-III) prezentējošas mutantās HBc VLP. Pētījumā tika pārbaudīta mutanto HBcAg spēja pakot specifiskas nukleīnskābes, kas darbojas kā adjuvanti, kā arī tika veikta DV2-III ķīmiskā konjugācija pie HBcAg VLP. Tomēr, salīdzinot DV2-III ķīmisko konjugāciju pie Qβ VLP, kas kā efektīvs svešu epitopu nesējs ir pierādīts vairākos pētījumos, uzrādīja labāku DV2-III ķīmiskās konjugācijas efektivitāti.

year	journal	country	edition	language
2017-01-01

https://dspace.lu.lv/dspace/handle/7/36179

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