6533b831fe1ef96bd1298cde
RESEARCH PRODUCT
ChemInform Abstract: Water in Stereoselective Organocatalytic Reactions
Francesco GiacaloneRenato NotoMichelangelo Gruttadauriasubject
chemistry.chemical_compoundchemistryOrganocatalysisEnantioselective synthesisIminiumStereoselectivityGeneral MedicineAsymmetric inductionCombinatorial chemistryCatalysisEnaminedescription
In this review, recent advances in asymmetric organocatalytic reactions carried out with variable amounts of water, from substoichiometric to a large excess (reaction medium), are discussed. We also summarize several proposed mechanisms for the different possibilities of the action of water both in the increased activity of the catalyst and in the asymmetric induction. Finally, the application of this catalytic methodology to the enantioselective synthesis of valuable compounds through enamine or iminium catalysis is presented.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2009-04-28 | ChemInform |