6533b831fe1ef96bd1298d19

RESEARCH PRODUCT

Acetogenins from Annonaceae

Bruno FigadèreAlain LaurensDiego CortesAndré Cavé

subject

chemistry.chemical_classificationAntitumor activitybiologyStereochemistryAbsolute configurationFatty acidbiology.organism_classificationUvaria acuminataUvaricinchemistry.chemical_compoundchemistryAnnonaceaeAcetogeninLactone

description

In 1982, Jolad et al. isolated uvaricin, a new antitumor agent, from the roots of Uvaria acuminata (Annonaceae), a bis-tetrahydrofuranoid fatty acid lactone (1) related to polyketides or acetogenins. However, it contained a number of original structural characteristics, particularly a linear acetogenin, a bis-tetrahydrofuran pattern flanked by hydroxyls and a terminal unsaturated lactone. Two years later, Dabrah and Sneden (2, 3 and Cortes et al. (4) described four new products presenting the same structural characteristics. Because these products formed a new class of natural compounds, and are only found in species belonging to the family of Annonaceae, they are commonly called acetogenins from Annonaceae.

yearjournalcountryeditionlanguage
1997-01-01
https://doi.org/10.1007/978-3-7091-6551-5_2