6533b831fe1ef96bd1298d60

RESEARCH PRODUCT

Interrelationship Among Morphology, Metabolism, and Proliferation of Tumor Cells in Monolayer and Spheroid Culture

Anneli BredelUlrich KarbachLeoni A. KunzStefan WalentaLutz VollrattWolfgang Mueller-klieser

subject

medicine.anatomical_structureMorphology (linguistics)Cell divisionCell cultureChemistryCellMonolayermedicineSpheroidMetabolismMitochondrionCell biology

description

Previous investigations have indicated a positive correlation between the proliferative and metabolic activities of tumor cells in monolayer culture (Freyer et al., 1984; Freyer and Sutherland, 1985; Walenta and Mueller-Klieser, 1987). On the other hand, no difference in the local oxygen consumption has been found between highly proliferating outer cell areas and non-proliferating inner cellular regions in multicellular tumor spheroids (Mueller-Klieser, 1984, 1987). Therefore, the interrelationship among metabolism, proliferation, and cellular morphology was investigated systematically in tumor cells both in monolayer and spheroid culture.

yearjournalcountryeditionlanguage
1989-01-01
https://doi.org/10.1007/978-1-4684-5643-1_96