6533b831fe1ef96bd1298e5f

RESEARCH PRODUCT

Visible Light-Induced Sulfonylation/Arylation of Styrenes in a Double Radical Three-Component Photoredox Reaction

Stefan PuschJonas KühlbornAdriana LuqueGita MatulevičiūtėGita MatulevičiūtėAlgirdas ŠAčkusDieter SchollmeyerTill OpatzMurat KucukdisliBenjamin LippLisa Marie Kammer

subject

chemistry.chemical_classification010405 organic chemistryChemistryBiomoleculeOrganic ChemistryPhotoredox catalysisGeneral Chemistry010402 general chemistryPhotochemistry01 natural sciencesCatalysis0104 chemical sciencesStyrenechemistry.chemical_compoundRadical formationVisible spectrum

description

Simultaneous sulfonylation/arylation of styrene derivatives is achieved in a photoredox-catalyzed three-component reaction using visible light. A broad variety of difunctionalized products is accessible in mostly excellent yields and high diastereoselectivity. The developed reaction is scalable and suitable for the modification of styrene-functionalized biomolecules. Mechanistic investigations suggest the transformation to be operating through a designed sequence of radical formation and radical combination.

yearjournalcountryeditionlanguage
2019-02-15
https://doi.org/10.26434/chemrxiv.7722020