6533b831fe1ef96bd12990fc

RESEARCH PRODUCT

Centenarians maintain miRNA biogenesis pathway while it is impaired in octogenarians.

Juan GambiniConsuelo BorrásJose ViñaMarta InglésEva Serna

subject

Ribonuclease III0301 basic medicineAgingmedia_common.quotation_subjectRNA polymerase IIKaryopherinsBioinformaticsDEAD-box RNA Helicases03 medical and health sciencesmicroRNAHumansGeneDroshamedia_commonAged 80 and overGeneticsbiologyAge FactorsLongevityUp-RegulationMicroRNAs030104 developmental biologybiology.proteinRNA Polymerase IITranscriptomeMiRNA biogenesisBiogenesisDevelopmental BiologyDicer

description

Centenarians but not octogenarians up regulate the expression of miRNAs, as we previously reported. We have looked into miRNA biogenesis. We show that RNA POL II, DROSHA, EXPORTIN 5 and DICER, are up-regulated in centenarians compared with octogenarians. Furthermore, factors involved in the control of these miRNAs biogenesis genes are also up-regulated in centenarians. Therefore, the up-regulation of miRNA expression in centenarians can be explained in part because miRNA biogenesis pathway is depressed in octogenarians (ordinary aging) while it is maintained in centenarians (extraordinary aging).

https://www.fundanet.incliva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=1460