GABAA agonista muscimola ietekme uz žurku atmiņu alcheimera slimības tipa modelī

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RESEARCH PRODUCT

GABAA agonista muscimola ietekme uz žurku atmiņu alcheimera slimības tipa modelī

subject

GABA streptozocīns Alcheimera slimība ūdens labirinta tests muscimols Farmācija

description

Darba mērķis bija noskaidrot GABAA agonista muscimola mazo devu ietekmi uz žurku atmiņu icv STZ AD tipa modelī. Lai noteiktu žurku iemācīšanos un atmiņu, tika veikti ūdens labirinta treniņtesti un fināla tests. Rezultāti rāda, ka icv STZ ievade žurkām izraisīja telpiskās atmiņas traucējumus. Muscimols abās devās (0,01 un 0,05 mg/kg) aizsargāja žurkas no STZ izraisītiem efektiem ūdens labirinta testā, uzlabojot to telpisko atmiņu, iemācīšanos un lokomotoro aktivitāti. Iegūtie dati ļauj secināt, ka muscimola mazo devu potenciāls ir intriģējošs jauno anti-AD terapiju izpētē un, ka būtu nepieciešama muscimola hronisko efektu izpēte minētajā modelī.

year	journal	country	edition	language
2015-01-01

https://dspace.lu.lv/dspace/handle/7/30878

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