6533b831fe1ef96bd1299446

RESEARCH PRODUCT

MRI Characterization of non-Gaussian water diffusion in the brain using Diffusion Kurtosis Imaging (DKI)

Giorgio ColluraCesare GagliardoSalvatore GalloStefania NiciMaurizio Marrale

subject

Settore MED/37 - NeuroradiologiaSettore MED/26 - NeurologiaMRI DWI DKI BrainSettore MED/36 - Diagnostica Per Immagini E RadioterapiaSettore FIS/07 - Fisica Applicata(Beni Culturali Ambientali Biol.e Medicin)

description

Diffusion tensor imaging (DTI) is the most commonly used technique to extract microstructural features from a set of diffusion-weighted images. In addition to the metrics obtained with DTI, diffusion kurtosis imaging (DKI) can provide non-Gaussian diffusion measures by means of the kurtosis tensor. DKI give an dimensionless measure that quantifies the deviation of the water diffusion displacement profile from the Gaussian distribution of unrestricted diffusion, providing a measure of the degree of diffusion hindrance or restriction. DKI has shown to be more sensitive to tissue microstructural changes in both normal and pathological neural tissue. The aim of this work is the description of the theory of DKI, the MRI protocol that we used for DKI acquisitions at 1.5T clinical scanner.

yearjournalcountryeditionlanguage
2016-01-01
http://hdl.handle.net/10447/190085