6533b831fe1ef96bd12994eb
RESEARCH PRODUCT
Endothelin: an endothelium-derived vasoactive peptide and its possible role in the pathogenesis of cerebral vasospasm
Alafaci CSalpietro FmIacopino DgLars EdvinssonTomasello Fsubject
CEREBRAL ARTERYSettore MED/27 - NeurochirurgiaEndothelinscerebral vasospasm endothelinCEREBRAL ARTERY; ENDOTHELIN; SUBARACHNOID HEMORRHAGE; RATSMuscle Smooth VascularRATSIschemic Attack TransientBasilar ArteryCerebrovascular CirculationENDOTHELINAnimalsVasoconstrictor AgentsSUBARACHNOID HEMORRHAGEMuscle Contractiondescription
The contractile response to endothelin has been examined in cerebral arteries from rats subjected to a prior subarachnoid haemorrhage (SAH) and compared with saline injected controls. Endothelin elicited strong concentration-dependent contraction of rat basilar artery segments. The response was slow in onset and long lasting. The endothelin-induced contraction was much stronger in the SAH compared to control animals. Our findings suggest a role of the peptide in the pathophysiology of cerebral vasospasm.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1991-06-01 |