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RESEARCH PRODUCT
Virazole (Ribavirin) a Cytostatic Agent
W. E. G. MüllerRudolf K. ZahnJosef Arendessubject
chemistry.chemical_compoundChemistryCell growthRibavirinMetabolismNucleosideMolecular biologySalicylic acidVirusDNAIncubation perioddescription
Virazole (1-β-D-ribofuranosyl-1,2,4-triazole-3carboxamide,ribavirin) is a synthetic triazol nucleoside with a broad spectrum of antiviral activity. But virazole affects the metabolism not only of virus infected cells. Virazole strongly inhibits the cell proliferation of mouse lymphoma cells (L 5178y), which were not infected with DNA- or RNA-viruses. Starting with 3 × 103 cells/ml and an incubation period of 72 hr, the drug reduces the cell proliferation to 50% (= ED50 concentration) in a concentration of 4,7 μM.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1978-01-01 |