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RESEARCH PRODUCT
Development and Scale-Up of the Electrochemical Dehalogenation for the Synthesis of a Key Intermediate for NS5A Inhibitors
Christoph BucherTomás R. GalvãoSiegfried R. WaldvogelMarkus BänzigerChristoph Gützsubject
Electrolytic cellOrganic ChemistryHalogenationNanotechnologyLaminar flowElectrochemistryCathodelaw.inventionchemistry.chemical_compoundchemistryChemical engineeringlawYield (chemistry)Physical and Theoretical ChemistrySelectivityDerivative (chemistry)description
The electrochemical 2-fold dehalogenation of a spirocyclopropane-proline derivative at leaded bronze was scaled-up in a divided batch-type electrolysis cell in good yield and excellent selectivity. The upscaling via a flow electrolysis cell was also successful. Conditions were elaborated employing a single cell passage for complete conversion. The keys here are the direct cooling of the cathode and ensuring a good laminar flow.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-09-23 | Organic Process Research & Development |