6533b831fe1ef96bd1299743

RESEARCH PRODUCT

Total Synthesis of (+)-Greek Tobacco Lactone

Juha H. SiitonenPetri M. Pihko

subject

chemistry.chemical_classificationStereospecificityChemistryStereochemistryOrganic ChemistryEnantioselective synthesisTotal synthesisLactone

description

An enantioselective, protecting-group-free, total synthesis of (+)-Greek tobacco lactone has been achieved by using an organocatalytic Mukaiyama–Michael reaction and a stereospecific oxa-Michael reaction as key steps.

https://doi.org/10.1055/s-0034-1378273