6533b831fe1ef96bd129981d
RESEARCH PRODUCT
In silico prediction of Leishmania major -specific CD8+ epitopes
Sven BroschJoerg KuharevStefan TenzerEsther Von StebutHans-georg RammenseeGer Van ZandbergenKirsten Dietze-schwonbergBeatrix Grewesubject
0301 basic medicineIn silicoDermatologyComputational biologyBiologybiology.organism_classificationLeishmaniaBiochemistryEpitope03 medical and health sciencesPrediction algorithms030104 developmental biology0302 clinical medicineImmunityLeishmania majorMolecular BiologyPathogenCD8030215 immunologydescription
Infections with Leishmania (L.) major induce protective IFN-γ-dependent Th1/Tc1 immunity in C57BL/6 mice as well as in immunocompetent humans. Even though antigen-specific immunity provides lifelong immunity against reinfection, a vaccine against this pathogen does not yet exist. Here, we compared the results obtained from in silico predictions of murine CD8-specific L. major peptides using the algorithm SYFPEITHI with the number and predicted affinity of known proteins/peptides. Our results indicate that the majority of "immunodominant" epitopes of L. major have not been identified so far; thus, computer-based prediction algorithms may aid the development of an effective vaccine.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2017-04-20 | Experimental Dermatology |