Pyrimido[5,4-c]pyrrolo[2,1-a]isoquinoline: a new potential DNA-interactive ring system

6533b831fe1ef96bd129984e

RESEARCH PRODUCT

Pyrimido[5,4-c]pyrrolo[2,1-a]isoquinoline: a new potential DNA-interactive ring system

Anna Maria Almerico Alessandra Montalbano Patrizia Diana Antonino Lauria Paola Barraja Gaetano Dattolo Girolamo Cirrincione

subject

Stereochemistry Organic Chemistry Intercalation (chemistry)Ring (chemistry)Decomposition Nmr data lcsh:QD241-441 chemistry.chemical_compound chemistry lcsh:Organic chemistry Acid catalyzed Azide Isoquinoline DNA

description

The acid catalyzed decomposition of the azide 9 failed to give the title compounds, which were however obtained by a Pschorr-type cyclization on reactive 1-(6-aminopyrimidin-5-yl)-pyrroles of type 13. Derivatives of type 14 and 15 were fully characterized by NMR data. Theoretical calculations demonstrated that the new compounds possess properties suitable for DNA- intercalation.

year	journal	country	edition	language
2003-01-22	ARKIVOC

10.3998/ark.5550190.0003.b24 https://www.arkat-usa.org/arkivoc-journal/browse-arkivoc/ark.5550190.0003.b24

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