Analysis of a soluble lipid-protein complex carrying endogenous 11-cis retinaldehyde from bovine retinal pigment epithelium.

6533b831fe1ef96bd1299877

RESEARCH PRODUCT

Analysis of a soluble lipid-protein complex carrying endogenous 11-cis retinaldehyde from bovine retinal pigment epithelium.

Maria Concetta Gueli Luisa Tesoriere Antonino Bono Maria A. Livrea Concetta M.a. Nicotra A. Bongiorno Leonardo Pandolfo

subject

medicine.medical_treatment Phagocytosis Lipoproteins Clinical Biochemistry Endogeny Biology Pigment Retinoids Cytosol medicine Animals Pigment Epithelium of Eye Molecular Biology Phospholipids Triglycerides chemistry.chemical_classification Cathepsin Protease Retinal pigment epithelium Cell Biology General Medicine Molecular Weight medicine.anatomical_structure Cholesterol chemistry Biochemistry visual_art Retinaldehyde visual_art.visual_art_medium Chromatography Gel Retinaldehyde Cattle Electrophoresis Polyacrylamide Gel Glycoprotein Carrier Proteins

description

A soluble lipid-protein complex in bovine retinal pigment epithelium is shown to carry endogenous 11-cis retinaldehyde, in the extent of 15% of the total 11-cis retinaldehyde found in this tissue. The complex, analyzed with respect to its chemical composition, exhibits a lipid composition close resembling the lipid composition of the rod outer segment membrane; the SDS-PAGE evidences the presence of a number of protein bands, two of which of 34 and 27 kDa appear glycoproteins. Finally, the lipid-protein complex exhibits a discrete level of a Cathepsin D-like protease activity. From the above, the possibility is discussed that the soluble lipid-protein complex could represent some phagolysosomal inclusion occurring in the pigment epithelial cells upon rod outer segment phagocytosis.

year	journal	country	edition	language
1989-02-21	Molecular and cellular biochemistry

10.1007/bf00577113 https://pubmed.ncbi.nlm.nih.gov/2725486

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