6533b831fe1ef96bd12998f3
RESEARCH PRODUCT
Characterization of interaction between tricyclic structures containing pharmaceuticals, their models and humic substances.
Andris ZicmanisLinda AnsoneOskars PurmalisMaris Klavinssubject
chemistry.chemical_classificationEnvironmental EngineeringQuenching (fluorescence)Molecular massMolecular Structurecomplex mixturesWaste Disposal FluidFluorescence spectroscopyCharacterization (materials science)Water PurificationHydrophobic effectchemistryPharmaceutical PreparationsIonic strengthOrganic chemistryHumic acidHumic SubstancesWater Pollutants ChemicalWater Science and TechnologyTricyclicdescription
Their persistence and wide consumption identify pharmaceuticals as “emerging pollutants”. The complexation of pharmaceuticals containing adamantine ring structures and their model substances with humic acids (HA) of different origins was compared using fluorescence spectroscopy as a function of pH, humic acid concentration, ionic strength, and molecular mass of HA. Binding constants between the studied pharmaceuticals and humic acids were calculated. A combination of dynamic and static quenching processes as indicated by nonlinear Stern-Volmer plots and high Kd values were positively correlated with the concentration of carboxyl groups in the studied humic acids. For basic functional group-containing pharmaceuticals, the complexation was driven by cation exchange and hydrophobic interactions depending on the properties of the interacting compounds.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2011-03-01 | Water science and technology : a journal of the International Association on Water Pollution Research |