6533b831fe1ef96bd1299aa1

RESEARCH PRODUCT

Selective C-H Activation of Methoxy Groups in a Three-Component Photoreaction.

Guenther LahmTill Opatz

subject

chemistry.chemical_compoundchemistryRadicalOrganic ChemistryPhotocatalysisIminiumOrganic chemistryDimethoxymethaneMedicinal chemistry

description

Surprisingly, the photocatalytic activation of ethers by H-abstraction and addition of the generated radicals to iminium ions formed in situ from aldehydes and anilines predominantly yielded the products of methoxy activation for dimethoxymethane and 1,2-dimethoxyethane. Various anilines and aromatic as well as aliphatic aldehydes are suitable reaction partners for this three-component photoreaction (Porta-type process) which also provides a simple access to 1,2-aminoalcohols.

10.1021/acs.joc.5b02373https://pubmed.ncbi.nlm.nih.gov/26575961