6533b831fe1ef96bd1299b38
RESEARCH PRODUCT
Efficient synthesis of new C-functionalized macrocyclic polyamines
Roger GuilardYoann RousselinFrédéric BoschettiNicolas SokFranck Denatsubject
amines010402 general chemistry01 natural sciencesAldehydeChemical synthesischemistry.chemical_compoundN ligands[ CHIM.ORGA ] Chemical Sciences/Organic chemistryOrganic chemistryChelationPhysical and Theoretical ChemistryBifunctionalComputingMilieux_MISCELLANEOUSchemistry.chemical_classification010405 organic chemistryLigand[CHIM.ORGA]Chemical Sciences/Organic chemistryOrganic ChemistrySynthonRegioselectivity0104 chemical sciences3. Good healthmacrocycleschemistryFunctional groupbifunctional chelating agentsdescription
A powerful synthetic route for the preparation of new poly-azamacrocycles, valuable precursors of bifunctional chelating agents with applications in nuclear medicine, is reported. The desired functional group was introduced onto the macro-cycle backbone during the cyclization step, thus avoiding the tedious preparation of a C-functionalized synthon. The regioselective reaction of macrocycles bearing an aminomethyl pendant arm with aldehydes is also described.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2010-03-01 |