6533b831fe1ef96bd1299b94
RESEARCH PRODUCT
A meta-analysis of 120 246 individuals identifies 18 new loci for fibrinogen concentration
Riccardo E. MarioniChristopher J. O'donnellOscar H. FrancoJohan ErikssonFrancesco CuccaJonathan MartenAlexander P. ReinerTim D. SpectorPhilipp S. WildPaul MitchellWolfgang KoenigBarbara McknightJ. Wouter JukemaAlan F. WrightMaria Sabater-llealCharles KooperbergAlbert HofmanTalin HarituniansMartina Müller-nurasyidJie HuangJie YaoMarcus E. KleberPau NavarroNicholas L. SmithJennifer E. HuffmanLynda M. RoseRussell P. TracyAntti-pekka SarinAntti-pekka SarinStefania BandinelliIan J. DearyAarno PalotieSaonli BasuCaroline HaywardKent D. TaylorWinfried MärzAaron R. FolsomAnne GrotevendtLawrence F. BielakTarunveer S. AhluwaliaMing-huei ChenAlexander TeumerGraciela E. DelgadoSharon L.r. KardiaPeter K. JoshiWendy L. McardleToshiko TanakaJing Hua ZhaoDiane M. BeckerPierre-emmanuel MorangeAlanna C. MorrisonAnnette KifleyIgor RudanLorna M. LopezLorna M. LopezKay-tee KhawNicholas J. WarehamEco J. C. De GeusMohsen GhanbariJari LahtiTatijana ZemunikJohn M. StarrMagdalena ZoledziewskaAnuj GoelDena G. HernandezAbbas DehghanOzren PolasekMelanie WaldenbergerHelene RiessRodney J. ScottQiong YangRobert A. ScottNancy S. JennyJohanna MazurWeihong TangPaul M. RidkerPaul M. RidkerTorben HansenAnders HamstenJames F. WilsonJouke J. HottengaCristina VenturiniPaul L. AuerGeoffrey H. ToflerPirro G. HysiMark G. McevoyAnn RumleyFernando RivadeneiraNaveed SattarIvana KolcicJie Jin WangJingmin LiuStella TrompetElizabeth G. HollidaySarah H. WildMaristella SteriUwe VölkerTanja ZellerPatricia A. PeyserP. Eline SlagboomMassimo ManginoAndré G. UitterlindenPaul S. De VriesDorret I. BoomsmaHarry CampbellVera GrossmannGonneke WillemsenKatri RäikkönenEdoardo FiorilloAres Rocanin-arjoGordon D.o. LoweDavid P. StrachanAnton J. M. De CraenMoniek P.m. De MaatDavid-alexandre TrégouëtJennifer A. BrodyRehan QayyumLisa R. YanekLuigi FerrucciAndreas GreinacherLewis C. BeckerHugh WatkinsDavid J. StottMin A. JhunTina L. BerentzenAnnette PetersBengt SennbladDaniel I. ChasmanDaniel I. ChasmanLihong QiChristopher OldmeadowHarald BinderXiuqing GuoJohn AttiaBruce M. Psatysubject
AdultMale0301 basic medicineNetherlands Twin Register (NTR)Single-nucleotide polymorphismGenome-wide association studyBiologyPolymorphism Single NucleotideWhite People03 medical and health sciencesINDEL MutationGenetics/dk/atira/pure/keywords/cohort_studies/netherlands_twin_register_ntr_Humans1000 Genomes ProjectInternational HapMap ProjectIndelMolecular BiologyGenetics (clinical)ComputingMilieux_MISCELLANEOUSAgedGenetic associationAged 80 and overGeneticsAssociation Studies ArticlesFibrinogen[SDV.MHEP.HEM]Life Sciences [q-bio]/Human health and pathology/HematologyGeneral MedicineMiddle AgedGenetic architecture030104 developmental biologyGenetic LociFemaleGENOME-WIDE ASSOCIATION ; C-REACTIVE PROTEIN ; CARDIOVASCULAR-DISEASE ; CIRCULATING FIBRINOGEN ; GENETIC ARCHITECTURE ; VARIANTS ; DESIGN ; HEMOSTASIS ; RESOURCE ; HEALTHImputation (genetics)Genome-Wide Association Studydescription
Genome-wide association studies have previously identified 23 genetic loci associated with circulating fibrinogen concentration. These studies used HapMap imputation and did not examine the X-chromosome. 1000 Genomes imputation provides better coverage of uncommon variants, and includes indels. We conducted a genome-wide association analysis of 34 studies imputed to the 1000 Genomes Project reference panel and including similar to 120 000 participants of European ancestry (95 806 participants with data on the X-chromosome). Approximately 10.7 million single-nucleotide polymorphisms and 1.2 million indels were examined. We identified 41 genome-wide significant fibrinogen loci ; of which, 18 were newly identified. There were no genome-wide significant signals on the X-chromosome. The lead variants of five significant loci were indels. We further identified six additional independent signals, including three rare variants, at two previously characterized loci: FGB and IRF1. Together the 41 loci explain 3% of the variance in plasma fibrinogen concentration.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2015-11-10 |