Development of lung on a chip model for SARS-CoV-2 research

6533b832fe1ef96bd1299cff

RESEARCH PRODUCT

Development of lung on a chip model for SARS-CoV-2 research

Artis Galvanovskis

subject

SARS-CoV-2 orgāni uz čipa Bioloģija plaušas uz čipa

description

Kopš 2019. gada beigām pasauli plosa SARS-CoV-2 izraisītā COVID-19 pandēmija. Lai gan COVID-19 vakcīnas ir tikušas izstrādātas rekordlielā ātrumā, pandēmija ir akcentējusi nepieciešamību padziļināti pētīt koronavīrusus, kā arī sagatavoties nākotnes respiratorām infekcijām. Lai nodrošinātu ātru atbildi pret jaunām respiratorām infekcijām, ir jāpilnveido in vitro modeļi, kas ļautu ātrāk pārprofilēt esošās zāles un izstrādāt jaunas priekš šīm infekcijām. Ņemot vērā orgānu uz čipa sistēmu pielietošanu dažādu slimību pētniecībā, šajā bakalaura darbā tika izveidota plaušas uz čipa sistēma. Tajā tika optimizēta funkcionalizēšana, plūsma un šūnu uzsēšana. Tā tika raksturota ar imūnfluorescenci un 3D mikroskopiju. Tika novērota veiksmīga A549 un HUVEC kopkultūra un validēts 3D izkārtojums. Tika izskaidroti soļi tālākai sistēmas uzlabošanai.

year	journal	country	edition	language
2021-01-01

https://dspace.lu.lv/dspace/handle/7/54499

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