6533b832fe1ef96bd1299f40

RESEARCH PRODUCT

Specific Hippocampal Interneurons Shape Consolidation of Recognition Memory

Jose F. Oliveira Da CruzArnau Busquets GarciaZhe ZhaoMarjorie VarilhGianluca LavancoLuigi BellocchioLaurie RobinAstrid CannichFrancisca Julio KalajzićThierry Lesté LasserreMarlène MaîtreFilippo DragoGiovanni MarsicanoEdgar Soria Gómez

subject

MaleAnimals CB1 receptor D1 receptor Dopamine Endocannabinoid system GABA Hippocampus Interneurons Long-term potentiation Male Memory Mice Novel object recognition Recognition PsychologyCB1 receptorCB1 cannabinoid receptorsD(1) receptorhippocampus[SDV]Life Sciences [q-bio]D1 receptorneuronsCB(1) receptorArticleCA1informationMiceGABAMemoryAnimalsendocannabinoid systemlong-term potentiationinterneuronsmusculoskeletal neural and ocular physiologyRecognition Psychologyepisodic memoryinhibition[SDV] Life Sciences [q-bio]modulationnervous systemdopamineLTPnovel object recognition memory

description

Summary A complex array of inhibitory interneurons tightly controls hippocampal activity, but how such diversity specifically affects memory processes is not well understood. We find that a small subclass of type 1 cannabinoid receptor (CB1R)-expressing hippocampal interneurons determines episodic-like memory consolidation by linking dopamine D1 receptor (D1R) signaling to GABAergic transmission. Mice lacking CB1Rs in D1-positive cells (D1-CB1-KO) display impairment in long-term, but not short-term, novel object recognition memory (NOR). Re-expression of CB1Rs in hippocampal D1R-positive cells rescues this NOR deficit. Learning induces an enhancement of in vivo hippocampal long-term potentiation (LTP), which is absent in mutant mice. CB1R-mediated NOR and the associated LTP facilitation involve local control of GABAergic inhibition in a D1-dependent manner. This study reveals that hippocampal CB1R-/D1R-expressing interneurons control NOR memory, identifying a mechanism linking the diversity of hippocampal interneurons to specific behavioral outcomes.

yearjournalcountryeditionlanguage
2020-08-18
10.1016/j.celrep.2020.108046http://hdl.handle.net/10810/49144