6533b832fe1ef96bd129a121

RESEARCH PRODUCT

Investigation of fungicidal activity of 3-piperazine-bis(benzoxaborole) and its boronic acid analogue

Andrzej SporzyńskiDorota WieczorekKrzysztof M. BorysAgnieszka Adamczyk-woźniakJacek Lipok

subject

biologyStereochemistryAspergillus nigerfood and beveragesGeneral Chemistrybiology.organism_classificationInorganic Chemistrychemistry.chemical_compoundPiperazinechemistryAmphotericin BmedicineAspergillus terreusPhenylboronic acidFusarium solaniBoronic acidmedicine.drugPenicillium ochrochloron

description

3-Piperazine-bis(benzoxaborole) and its bis(phenylboronic acid) analogue were investigated in terms of their fungicidal activity. The study was carried out against five filamentous fungi: Aspergillus terreus, Fusarium dimerum, Fusarium solani, Penicillium ochrochloron and Aspergillus niger. 3-Piperazine-bis(benzoxaborole) revealed higher inhibitory activity towards the examined strains than standard antibiotic (amphotericin B), whereas bis(phenylboronic acid) proved to be inactive. The study unequivocally showed that the presence of the heterocyclic benzoxaborole system is essential for antifungal action of the examined compounds. Copyright © 2014 John Wiley & Sons, Ltd.

yearjournalcountryeditionlanguage
2014-03-13Applied Organometallic Chemistry
https://doi.org/10.1002/aoc.3132