Optimization of Resolving Power, Fragmentation, and Mass Calibration in an Orbitrap Spectrometer for Analysis of 24 Pesticide Metabolites in Urine

6533b832fe1ef96bd129a36c

RESEARCH PRODUCT

Optimization of Resolving Power, Fragmentation, and Mass Calibration in an Orbitrap Spectrometer for Analysis of 24 Pesticide Metabolites in Urine

Pablo Dualde Vicent Yusà Agustín Pastor Clara Coscollà

subject

Materials science Chromatography lcsh:QD71-142 Article Subject Collision-induced dissociation Spectrometer 010401 analytical chemistry lcsh:Analytical chemistry 02 engineering and technology Urine 021001 nanoscience & nanotechnology Mass spectrometry Orbitrap 01 natural sciences 0104 chemical sciences Analytical Chemistry law.invention Fragmentation (mass spectrometry)law 0210 nano-technology Research Article

description

Mass spectrometer parameters such as Resolving Power, type of fragmentation, and mass calibration mode were optimized in the analysis of 24 pesticide metabolites in human urine using Ultra-High Pressure Liquid Chromatography coupled to Orbitrap High-Resolution Mass Spectrometer (UHPLC-HRMS). The best results were achieved with a Resolving Power of 25,000 FWHM and by applying Collision Induced Dissociation fragmentation mode (40 eV).

year	journal	country	edition	language
2019-01-01

https://fundanet.fisabio.san.gva.es/publicaciones/ProdCientif/PublicacionFrw.aspx?id=3644

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