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RESEARCH PRODUCT

Mechanical Characterization of Polysaccharide/polyaminoacid Hydrogels as Potential Scaffolds for Tissue Regeneration

Giovanna PitarresiClaudia CencettiAntonella AlbaneseCalogero FioricaGaetano GiammonaGaetano GiammonaTommasina CovielloPietro MatricardiFabio Salvatore PalumboChiara Di Meo

subject

chemistry.chemical_classificationMaterials sciencePolymers and PlasticsGeneral Chemical EngineeringRegeneration (biology)Organic Chemistrytechnology industry and agriculturemacromolecular substancesfibroblast attachment; hyaluronic acid; mechanical properties; polyaspartamide; scaffoldsPolysaccharidePolymer engineeringCharacterization (materials science)chemistry.chemical_compoundchemistryhyaluronic acid polyaspartamide scaffolds mechanical properties fibroblast attachment.Settore CHIM/09 - Farmaceutico Tecnologico ApplicativoHyaluronic acidPolymer chemistrySelf-healing hydrogelsMaterials ChemistryBiophysics

description

The mechanical properties of hydrogel scaffolds based on hyaluronic acid (HA) that were chemically crosslinked with α,β-poly(N-2-hydroxyethyl)(2-aminoethylcarbamate)-D,L-aspartamide (PHEA-EDA) were investigated. Variation of these properties as a function of three different PHEA-EDA amounts used to crosslink HA has been related to the reaction efficiency evaluated using a colorimetric assay. Moreover, the amount of unreacted amino groups that was still present in the hydrogels was related to the attachment behavior of human dermal fibroblasts to the hydrogel surface. The mechanical data and biological results suggest the suitability of the investigated hydrogels as scaffolds for the regeneration of soft tissues such as skin. Open image in new window

yearjournalcountryeditionlanguage
2011-11-03
10.1007/s13233-011-1208-yhttp://hdl.handle.net/10447/62405