6533b832fe1ef96bd129a420

RESEARCH PRODUCT

γδ T Cells Cross-Link Innate and Adaptive Immunity in Mycobacterium tuberculosis Infection

Francesco DieliSary El DakerAngelo MartinoFederico MartiniSerena Meraviglia

subject

lcsh:Immunologic diseases. AllergyT-LymphocytesT cellImmunologyReview ArticleAdaptive ImmunityLymphocyte ActivationMycobacterium tuberculosisImmune systemAntigenImmunitymedicineAnimalsHumansTuberculosisImmunology and AllergyIL-2 receptorAntigen-presenting cellbiologyReceptors Antigen T-Cell gamma-deltaMycobacterium tuberculosisGeneral MedicineAcquired immune systembiology.organism_classificationVirologyImmunity Innategamma delta T cells Mycobacterium tuberculosismedicine.anatomical_structureImmunologylcsh:RC581-607Immunologic Memory

description

Protective immunity against mycobacterial infections such asMycobacterium tuberculosisis mediated by interactions between specific T cells and activated antigen presenting cells. To date, many aspects of mycobacterial immunity have shown that innate cells could be the key elements that substantially may influence the subsequent adaptive host response. During the early phases of infection, innate lymphocyte subsets play a pivotal role in this context. Here we summarize the findings of recent investigations onγδT lymphocytes and their role in tuberculosis immunity.

yearjournalcountryeditionlanguage
2011-01-01
http://hdl.handle.net/10447/58920