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RESEARCH PRODUCT

Impact of olanzapine on cognitive functions in patients with schizophrenia during an observation period of six months

subject

description

Objective: The objective of our study was to evaluate the effect of olanzapine treatment on selected cognitive functions in patients suffering from schizophrenia during an observation period of six-months. Subjects and methods: Twenty patients with a diagnosis of schizophrenia according to ICD-10 criteria for research were examined. One day before initiation of olanzapine a baseline assessment was perfor med. The neuropsychological examination was repeated 28 days, 60 days, 3 months, and 6 months after the be ginning of treatment. Cognitive function measurements were performed using Signal, COGNITRON and RT tests, being a part of the computer -based Vienna Test System (VTS). Results: Our study showed an improvement in the assessed cogniti ve functions. Impairments in co gnitive domains were observed at baseline as compared to published norma tive data, and enhancement in achieved results was observed subsequently in all stage s of the treatment until the 6th month. Conclusion: The above results are consistent with a number of othe r studies on the impact on cognitive functioning in patients with schizophrenia treated with olanzapine.