Antidiabētiskā medikamenta metformīna lietošanas ietekme uz cilvēka zarnu mikrobiomu

6533b832fe1ef96bd129a7de

RESEARCH PRODUCT

Antidiabētiskā medikamenta metformīna lietošanas ietekme uz cilvēka zarnu mikrobiomu

subject

metformīns 16S rRNS zarnu mikrobioms cukura diabēts Bioloģija

description

Metformīns ir plaši lietots medikaments 2. tipa cukura diabēta ārstēšanā. Pastāv hipotēze, ka metformīna ietekme uz organismu daļēji varētu tikt skaidrota ar tā mijiedarbību ar zarnu mikrobiomu. Bakalaura darba mērķis bija noskaidrot, kā metformīns ietekmē zarnu mikrobioma kompozīciju. Darba ietvaros tika izdalīta mikrobiālā DNS no astoņu cilvēku fēču paraugiem, kas bija ievākti dažādos laika posmos no metformīna lietošanas uzsākšanas, un, izmantojot lielapjoma paralēlo sekvenēšanu, veikta 16S rRNS V3 reģiona analīze, lai salīdzinātu mikrobioma kompozīciju. Pēc nedēļu ilgas metformīna lietošanas tika novērotas būtiskas izmaiņas vairāku taksonomisko vienību īpatsvarā un mikrobioma iekšējās daudzveidības samazināšanās. Darbs veikts no 10.2014. līdz 05.2015. Latvijas Biomedicīnas pētījumu un studiju centrā.

year	journal	country	edition	language
2015-01-01

https://dspace.lu.lv/dspace/handle/7/29464

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