D-pantenola saturošu preparātu un SIA "LMP" ražotā Bepaderm G gela stabilitātes pētījumi un sastāva optimizēšana

6533b832fe1ef96bd129a7f6

RESEARCH PRODUCT

D-pantenola saturošu preparātu un SIA "LMP" ražotā Bepaderm G gela stabilitātes pētījumi un sastāva optimizēšana

subject

hipromeloze karbomērs dekspantenols Farmācija urea spektrofotometrija

description

Gels sastāv no vairāku vielu komponentiem- aktīvās vielas, šķīdinātāja, biezinātājvielas, emulgatora, konservanta u.c. vielām. Šo vielu savstarpējā mijiedarbība nodrošina preparāta stabilitāti, farmakoloģisko darbību un nosaka tā uzglabāšanas laiku. Mērķis ir izvērtēt esošo dekspantenolu saturošo preparātu sastāvus un optimizēt SIA “LMP” ražotā Bepaderm G gela sastāvu. Darba gaitā tika izvērtēti dažādu ražotāju dekspantenolu saturošu gelu un krēmu sastāvi, veikti SIA “LMP” ražotā Bepaderm G gela stabilitātes pētījumi un izveidoti jauni dekspantenolu saturošu gelu paraugi. Rezultātā tika konstatēts, ka gan karbomērs, gan hipromeloze ir pietiekami labas gela biezinātājvielas, dekspantenola koncentrācija paraugos bija pietiekami augsta. Bepaderm G gels nav pietiekami stabils 40oC un 75oC temperatūrās.

year	journal	country	edition	language
2019-01-01

https://dspace.lu.lv/dspace/handle/7/48697

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