Pentafluoroethylation of Carbonyl Compounds by HFC-125 via the Encapsulation of the K Cation with Glymes

6533b832fe1ef96bd129ac70

RESEARCH PRODUCT

Pentafluoroethylation of Carbonyl Compounds by HFC-125 via the Encapsulation of the K Cation with Glymes

Kazuki Hirano Norio Shibata Norio Shibata Hideyuki Mimura Takumi Kagawa Yamato Fujihira Daniel M. Sedgwick Makoto Ono Santos Fustero

subject

Solvent chemistry 010405 organic chemistry Potassium Yield (chemistry)Organic Chemistry Polymer chemistry chemistry.chemical_element 010402 general chemistry 01 natural sciences 0104 chemical sciences Encapsulation (networking)

description

A simple protocol to overcome the explosive pentafluoroethylation of carbonyl compounds by HFC-125 is described. The use of potassium (K) bases with triglyme or tetraglyme as a solvent safely yield...

year	journal	country	edition	language
2021-03-29	The Journal of Organic Chemistry

https://doi.org/10.1021/acs.joc.1c00298

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