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RESEARCH PRODUCT
Role of iron, capsule, and toxins in the pathogenicity of Vibrio vulnificus biotype 2 for mice
Esperanza GarayElena G. BioscaBelén FouzCarmen AmaroA. E. Toranzosubject
Blood Bactericidal ActivityIronImmunologyExotoxinsVirulenceVibrio vulnificusIn Vitro Techniquesmedicine.disease_causeMicrobiologyMicrobiologyMiceSpecies SpecificityVibrionaceaeVibrio InfectionsmedicineAnimalsHumansVibrioEelsVirulencebiologyToxinLethal dosebiology.organism_classificationVibrioBacterial Typing TechniquesInfectious DiseasesVibrio InfectionsParasitologyBacteriaResearch Articledescription
The virulence mechanisms of Vibrio vulnificus biotype 2 have been studied and compared with those of biotype 1 in mice as the experimental animals. Biotype 2 isolates from European eels were as virulent for mice as biotype 1 strains (50% lethal dose, about 10(5) CFU per mouse); a septicemic infection developed in less than 24 h. These strains had several properties in common with biotype 1 organisms including capsule expression, uptake of various iron sources, and production of exoproteins, whose role in mouse virulence has been demonstrated. We also discuss the implication of biotype 2 strains in human infections.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1994-02-01 | Infection and Immunity |