Metformīna efekti uz uzvedību un glikozes homeostāzes traucējumiem Alcheimera slimības tipa modeļdzīvniekos

6533b832fe1ef96bd129b136

RESEARCH PRODUCT

Metformīna efekti uz uzvedību un glikozes homeostāzes traucējumiem Alcheimera slimības tipa modeļdzīvniekos

Aleksandra Gžibovska

subject

metformīns glikoze streptozocīns Alcheimera slimība neiroprotekcija Farmācija

description

Alcheimera slimība ir hroniska neirodeģeneratīva slimība, kas raksturojas ar progresējošu kognitīvo funkciju pavājināšanos. Šī darba mērķis bija noskaidrot metformīna efektus uz telpisko iemācīšanos un atmiņu žurku Alcheimera slimības modelī, kā arī noteikt metformīna ietekmi uz GLUT3 un GSK-3 ekspresiju šo dzīvnieku smadzeņu garozā un hipokampā. Ūdens labirinta testa rezultāti uzrādīja, ka metformīns uzlabo mācīšanās spējas un atmiņu Alcheimera slimības modeļa žurkām. Ar Western blot noskaidroja, ka metfromīns (75 vai 100 mg/kg) normalizē GLUT3 un GSK-3 ekspresiju žurku smadzeņu garozā un hipokampā pēc streptozocīna ievadīšanas līdz kontroles līmenim. Metformīns varētu būt efektīvs līdzeklis glikozes homeostāzes regulācijā pie Alcheimera slimības.

year	journal	country	edition	language
2019-01-01

https://dspace.lu.lv/dspace/handle/7/47823

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