6533b833fe1ef96bd129b5db
RESEARCH PRODUCT
Monocyte Interleukin-1 Secretion Is Regulated by the Sequential Action of γ-Interferon and Interleukin-2 Involving Monocyte Surface Expression of Interleukin-2 Receptors
Albrecht LindemannWolfgang OsterM. BrachJames D. GriffinStephen A. CannistraRoland MertelsmannFriedhelm Herrmannsubject
Interleukin 2medicine.anatomical_structureChemistryMonocytemedicineInterleukinSurface expressionSecretionγ interferonCleavage (embryo)ReceptorMolecular biologymedicine.drugdescription
Interleukin-1 (IL-1) is a polypeptide synthesized as a high-mol.-wt. precursor and subsequently secreted after proteolytic cleavage to 17500-dalton active forms in murine [1] and human cells [2]. Recently, cDNAs for murine [3] and for two distinct human IL-1 species, IL-1α and IL- 1β, have been isolated, sequenced, and cloned [2, 4].
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1989-01-01 |