6533b833fe1ef96bd129b657
RESEARCH PRODUCT
Synthesis of (–)-(S)-Norlaudanosine, (+)-(R)-O,O-Dimethylcoclaurine, and (+)-(R)-Salsolidine by Alkylation of an α-Aminonitrile
Nancy BlankTill OpatzFrank Wernersubject
DeprotonationSalsolidineStereochemistryChemistryOrganic ChemistryEnantioselective synthesisPhysical and Theoretical ChemistryAlkylationCarbanionUmpolungdescription
A short asymmetric synthesis of 1-substituted 1,2,3,4-tetrahydroisoquinoline alkaloids by deprotonation of an unprotected α-aminonitrile and alkylation of the resulting carbanion followed by spontaneous elimination of HCN and asymmetric reduction is described. (© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2007)
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2007-08-01 | European Journal of Organic Chemistry |