6533b833fe1ef96bd129b753
RESEARCH PRODUCT
T-cell hyperreactivity of NZB mice against H-2 identical cells
R. BartlettU. BotzenhardtJ. Müllersubject
T cellImmunologychemical and pharmacologic phenomenaurologic and male genital diseasesMiceRheumatologyimmune system diseasesAnimalsLupus Erythematosus SystemicImmunology and AllergyCytotoxic T cellMedicineskin and connective tissue diseasesMice Inbred BALB CMice Inbred NZBStrain (chemistry)business.industrySystemic lupusT-Lymphocytes Helper-InducerDisease Models AnimalCTL*medicine.anatomical_structureCytotoxic T-lymphocyte precursor frequencyImmunologybusinessT-Lymphocytes Cytotoxicdescription
NZB mice serve as a model for human systemic lupus erythematodes. T-cell abnormalities in this strain have previously been described. In this paper the cytotoxic T lymphocyte precursor (CTL-p) frequencies of NZB mice against H-2 allogeneic and H-2 syngeneic cells are investigated and compared with those of the normal strain BALB/c. The CTL-p frequency in NZB lymphocytes against H-2 allogeneic cells equals that in normal mouse strains (i.e. 1/7500). The NZB anti BALB/c response is in the same order of magnitude. No corresponding BALB/c anti NZB response was elicited. The results suggest abnormally high sensitivity of NZB CTL-p to helper signals.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 1983-03-01 | Rheumatology International |