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RESEARCH PRODUCT
How Effective and Safe Is Bronchial Thermoplasty in “Real Life” Asthmatics Compared to Those Enrolled in Randomized Clinical Trials?
Carla GaleoneNicola FacciolongoGiuseppe FaillaSalvatore BattagliaAlba La SalaRita ArrigoAlida BenfanteScichilone Nicolasubject
Pediatricsmedicine.medical_specialtyPretreatment PeriodArticle SubjectMEDLINElcsh:MedicineSettore MED/10 - Malattie Dell'Apparato RespiratorioGeneral Biochemistry Genetics and Molecular Biologylaw.invention03 medical and health sciences0302 clinical medicineRandomized controlled triallawInternal medicineMedicineIn real life030212 general & internal medicineBronchial ThermoplastyGeneral Immunology and MicrobiologyBronchial thermoplastybusiness.industrylcsh:RGeneral MedicineAsthma030228 respiratory systemClinical StudySalbutamolbusinessmedicine.drugdescription
There is limited information on the efficacy and safety of bronchial thermoplasty (BT) inreal life. We evaluated the outcomes of the randomized clinical trials for BT in severe asthmatics, in whom the exclusion criteria were not strictly controlled. A case series of seven asthmatics (M/F: 4/3; age:54.6±2.9years) is reported. Subjects had a statistically significant improvement in AQLQ (from a mean of3.96±1.1to4.5±1.2and5.5±0.6after 6 and 12 months of treatment;p=0.0007) and in the ACQ score (from2.77±0.8to1.83±1.2and1.5±0.8after 6 and 12 months;p<0.001). In the year after BT, severe exacerbations, salbutamol use, and OCS use were significantly lower compared with the 1-yr pretreatment period (p<0.001). No ED visits and hospitalization occurred in the year after BT. No changes in functional parameters were recorded. Our investigation confirms the safety and efficacy of BT in severe asthmatics inreal lifesettings.
| year | journal | country | edition | language |
|---|---|---|---|---|
| 2016-06-20 | BioMed Research International |